The Coolest RSS

Archive

Apr
24th
Thu
permalink
Apr
23rd
Wed
permalink

piercingsandink:

imalonelywhale:

thehunterandherangel:

balancedwithshadow:

thesataniclokeanrebel:

vanderwolf:

wholeheartedlyhalfhearted:

theclocktowerguardian:

dorkmeetstumblr:

acanthachaos:

I find this so adorable :3💜

THIS IS SO FUCKING CUTE. #thedream

For Amber

Women like this don’t actually exist, do they?

excuse you 

We exist all over the goddamn place.

I am like this thank you very much!

this will be us hehe

This is literally my relationship.

oh my god this is so freaking cute and that last picture omfg HAHAHA

(via rainbowcupquakes)

permalink

gothstoner:

this is how i make out

(Source: nichiyou, via nico-le)

permalink

(Source: , via sexytattooedgirls)

permalink

lafemmegeekita:

Jenny Parks Illustrations understands the importance of Caturday!  I’ve only included my favorite prints.  You can check the rest out here.

(via kisstini)

permalink
permalink

strikeblr:

God damn it

(Source: prettyprettyday, via ionlyliftontuesdays)

permalink
neurosciencestuff:

Scientists Identify Critical New Protein Complex Involved in Learning and Memory
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a protein complex that plays a critical but previously unknown role in learning and memory formation.
The study, which showed a novel role for a protein known as RGS7, was published April 22, 2014 in the journal eLife, a publisher supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.
“This is a critical building block that regulates a fundamental process—memory,” said Kirill Martemyanov, a TSRI associate professor who led the study. “Now that we know about this important new player, it offers a unique therapeutic window if we can find a way to enhance its function.”
The team looked at RGS7 in the hippocampus, a small part of the brain that helps turn short-term memory in long-term memory.
The scientists found the RGS7 protein works in concert with another protein, R7BP, to regulate a key signaling cascade that is increasingly seen as a critical to cognitive development. The cascade involves the neurotransmitter GABA, which binds to the GABAb receptor and opens inhibitory channels known as GIRKs in the cell membrane. This process ultimately makes it more difficult for a nerve cell to fire.
This process turned out to be critical to normal functioning, as the research showed mice lacking RGS7 exhibited deficits in learning and memory.
Martemyanov believes the findings could ultimately have broad therapeutic application. “GIRK channels are implicated in a range of neuropsychiatric conditions, including drug addiction and Down’s syndrome, that result from a disproportionate increase in neuronal inhibition as a result of greater mobilization of these channels,” he said. “Now that we know the identity of the critical modulator of GIRK channels we can try to find a way to increase its power with the hopes of reducing the inhibitory overdrive, and that might potentially alleviate some of the  disruptions seen in Down’s syndrome. It is possible that similar strategies might apply for dealing with addiction, where adaptations in the GABAb-GIRK pathway play a significant role.”
Targeting the RGS7 protein could allow for better therapeutic outcomes with fewer side effects because it allows for fine tuning of the signaling, according to Olga Ostrovskaya, the first author of the study and a member of Martemyanov’s lab, who sees many ways to follow up on the findings.
“We’re looking into how RGS7 is involved in neural circuitry and functions tied to the striatum, another part of the brain responsible for procedural memory, mood disorders, motivation and addiction,” Ostrovskaya said. “We may uncover the RGS7 regulation of other signaling complexes that may be very different from those in hippocampus.”

neurosciencestuff:

Scientists Identify Critical New Protein Complex Involved in Learning and Memory

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a protein complex that plays a critical but previously unknown role in learning and memory formation.

The study, which showed a novel role for a protein known as RGS7, was published April 22, 2014 in the journal eLife, a publisher supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.

“This is a critical building block that regulates a fundamental process—memory,” said Kirill Martemyanov, a TSRI associate professor who led the study. “Now that we know about this important new player, it offers a unique therapeutic window if we can find a way to enhance its function.”

The team looked at RGS7 in the hippocampus, a small part of the brain that helps turn short-term memory in long-term memory.

The scientists found the RGS7 protein works in concert with another protein, R7BP, to regulate a key signaling cascade that is increasingly seen as a critical to cognitive development. The cascade involves the neurotransmitter GABA, which binds to the GABAb receptor and opens inhibitory channels known as GIRKs in the cell membrane. This process ultimately makes it more difficult for a nerve cell to fire.

This process turned out to be critical to normal functioning, as the research showed mice lacking RGS7 exhibited deficits in learning and memory.

Martemyanov believes the findings could ultimately have broad therapeutic application. “GIRK channels are implicated in a range of neuropsychiatric conditions, including drug addiction and Down’s syndrome, that result from a disproportionate increase in neuronal inhibition as a result of greater mobilization of these channels,” he said. Now that we know the identity of the critical modulator of GIRK channels we can try to find a way to increase its power with the hopes of reducing the inhibitory overdrive, and that might potentially alleviate some of the  disruptions seen in Down’s syndrome. It is possible that similar strategies might apply for dealing with addiction, where adaptations in the GABAb-GIRK pathway play a significant role.”

Targeting the RGS7 protein could allow for better therapeutic outcomes with fewer side effects because it allows for fine tuning of the signaling, according to Olga Ostrovskaya, the first author of the study and a member of Martemyanov’s lab, who sees many ways to follow up on the findings.

“We’re looking into how RGS7 is involved in neural circuitry and functions tied to the striatum, another part of the brain responsible for procedural memory, mood disorders, motivation and addiction,” Ostrovskaya said. “We may uncover the RGS7 regulation of other signaling complexes that may be very different from those in hippocampus.”

Apr
22nd
Tue
permalink

bitelchus:

swatlock:

Pop Culture References in Shrek 2 (1/?)

Click the gifs for more information

OH MY GOD, IM SO GLAD I FOUND THIS ON MY DASH.

I´VE BEEN LOOKING FOR IT FOR AGES. 

(via rainbowcupquakes)

permalink

nonespark:

chibisilverwings:

ambrromance:

joultonofblood:

Sums up their personalities pretty well.

Eddy: I can achieve anything
Edd: there’s a logical way to achieve what I want
Ed: there’s nothing standing in my way

Eddy hopping over the fence indicates his willingness to “cheat” the system, or to take a shortcut. Much like his schemes, it might end up being more work, but in his mind, cheating is the best way to get ahead.

Edd goes the neat and logical way, he’s straight forward. BUT, note that he closes the gate behind him rather than leaving it open. He’s incredibly meticulous and even if it’s more convenient to leave it open for anyone coming in behind him, he has to leave things neat, tidy and as he found them.

Ed is also is straight forward, he in fact is using the MOST direct route. But this route is one no one else would consider because it seems completely nonsensical. Which sums him up pretty well. The fact that it works for him is also fun to note. In general his earnestness and determination carries him through situations that most people would be stopped by.

this got very analytical very quickly.

and that’s fine, but i would also like to point out that is the first gif Double D slides over to the door and as soon as he stops he’s Eddy.

(Source: greenwithenby, via rainbowcupquakes)